{"id":5246,"date":"2026-02-07T16:23:53","date_gmt":"2026-02-07T16:23:53","guid":{"rendered":"https:\/\/www.saludquiropractica.es\/regulacion-neurologica-y-percepcion-del-dolor\/"},"modified":"2026-02-07T16:23:53","modified_gmt":"2026-02-07T16:23:53","slug":"regulacion-neurologica-y-percepcion-del-dolor","status":"publish","type":"post","link":"https:\/\/www.saludquiropractica.es\/en\/regulacion-neurologica-y-percepcion-del-dolor\/","title":{"rendered":"Neurological regulation and pain perception"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_1 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.saludquiropractica.es\/en\/regulacion-neurologica-y-percepcion-del-dolor\/#Regulacion_neurologica_y_percepcion_del_dolor_que_significan_y_por_que_importan\" >Neurological regulation and pain perception: what they mean and why they matter<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.saludquiropractica.es\/en\/regulacion-neurologica-y-percepcion-del-dolor\/#Como_actuan_las_vias_nerviosas_y_los_neurotransmisores_en_la_regulacion_neurologica_de_la_percepcion_del_dolor\" >How nerve pathways and neurotransmitters act in the neurological regulation of pain perception<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.saludquiropractica.es\/en\/regulacion-neurologica-y-percepcion-del-dolor\/#Factores_que_pueden_modular_la_regulacion_neurologica_y_la_percepcion_del_dolor_estres_sueno_actividad_fisica\" >Factors that can modulate neurological regulation and perception of pain (stress, sleep, physical activity).<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.saludquiropractica.es\/en\/regulacion-neurologica-y-percepcion-del-dolor\/#Estres\" >Stress<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.saludquiropractica.es\/en\/regulacion-neurologica-y-percepcion-del-dolor\/#Sueno\" >Dream<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.saludquiropractica.es\/en\/regulacion-neurologica-y-percepcion-del-dolor\/#Actividad_fisica\" >Physical activity<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.saludquiropractica.es\/en\/regulacion-neurologica-y-percepcion-del-dolor\/#Diferencias_entre_dolor_agudo_cronico_y_neuropatico_en_la_regulacion_neurologica_y_la_forma_de_percibirlo\" >Differences between acute, chronic and neuropathic pain in neurological regulation and perception of pain<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.saludquiropractica.es\/en\/regulacion-neurologica-y-percepcion-del-dolor\/#Dolor_agudo\" >Acute pain<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.saludquiropractica.es\/en\/regulacion-neurologica-y-percepcion-del-dolor\/#Dolor_cronico\" >Chronic pain<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.saludquiropractica.es\/en\/regulacion-neurologica-y-percepcion-del-dolor\/#Dolor_neuropatico\" >Neuropathic pain<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.saludquiropractica.es\/en\/regulacion-neurologica-y-percepcion-del-dolor\/#Opciones_terapeuticas_con_base_cientifica_para_apoyar_la_regulacion_neurologica_y_una_percepcion_del_dolor_mas_tolerable\" >Science-based therapeutic options to support neurological regulation and a more tolerable perception of pain<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Regulacion_neurologica_y_percepcion_del_dolor_que_significan_y_por_que_importan\"><\/span>Neurological regulation and pain perception: what they mean and why they matter<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The <b>neurological regulation<\/b> is the ability of the nervous system to filter, amplify or attenuate signals related to potential harm. The <b>perception of pain<\/b> is not equivalent to the <b>nociception<\/b> (detection of noxious stimuli); it is a sensory and emotional experience that integrates peripheral signals with central processes such as attention, memory and emotional state. Thus, pain can vary even if the tissue state does not change proportionally.<\/p>\n<p>This regulation involves circuits <b>ascending<\/b> (from peripheral receptors to the medulla, thalamus and cortex) and <b>descendants<\/b> (from brainstem and cortex to medulla) that exert inhibitory or facilitatory modulation via neurotransmitters such as glutamate, GABA, serotonin and noradrenaline. When the control mechanisms become imbalanced, the following can occur <b>central awareness<\/b>, The phenomena of allodynia (pain in response to non-painful stimuli) or hyperalgesia (increased pain response) are the result of changes in neuronal excitability and synaptic efficacy.<\/p>\n<p>Understanding these processes matters because it helps to interpret why pain can fluctuate and why it does not always reflect tissue status in a linear fashion. Factors such as sleep, stress, inflammation, physical activity, medication and cognitive-emotional context can influence pain modulation. In clinical practice, distinguishing between nociceptive, neuropathic or non-disciplastic profiles and recognising the role of neurological regulation guides more accurate assessments and prudent multimodal management decisions, without assuming uniform or guaranteed responses.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Como_actuan_las_vias_nerviosas_y_los_neurotransmisores_en_la_regulacion_neurologica_de_la_percepcion_del_dolor\"><\/span>How nerve pathways and neurotransmitters act in the neurological regulation of pain perception<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The perception of pain starts with nociception: potentially harmful stimuli activate <b>nociceptors<\/b> in peripheral tissues. A-delta and C-fibres conduct signals to the spinal cord, where they converge in the dorsal horn and synapse with interneurons and projection neurons. Excitatory neurotransmitters such as the <b>glutamate<\/b> and the <b>substance P<\/b> transmit the signal; discharge frequency and convergence determine the perceived intensity. From there, neurons move up (e.g., via the spinothalamic tract) to the thalamus, somatosensory cortex, insula and anterior cingulate, which integrate location, quality and intensity.<\/p>\n<p>At the segmental level, inhibitory interneurons releasing GABA and glycine attenuate nociceptive transmission and are involved in the \u00abnociceptive response\".\u00ab<b>gate control<\/b>\u00bbThe activation of A-beta tactile afferents can reduce the pain signal by reinforcing this inhibition. Changes in synaptic excitability due to inflammation or injury promote peripheral sensitisation and the <b>central awareness<\/b>, The expression of hyperalgesia and allodynia, phenomena clinically associated with hyperalgesia and allodynia, varies between individuals and clinical situations.<\/p>\n<p>Downstream modulation originates in the periaqueductal grey matter and brainstem nuclei (such as the rostroventromedial and locus coeruleus) and bidirectionally adjusts transmission in the medulla. Neurotransmitters such as serotonin and noradrenaline are involved, as well as <b>endogenous opioids<\/b> (enkephalins, endorphins), with inhibitory or facilitating effects depending on receptors and physiological state. Cortical networks linked to attention, emotion and expectations influence these pathways, modulating the painful experience without this effect being constant or predictable in all cases.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Factores_que_pueden_modular_la_regulacion_neurologica_y_la_percepcion_del_dolor_estres_sueno_actividad_fisica\"><\/span>Factors that can modulate neurological regulation and perception of pain (stress, sleep, physical activity).<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"Estres\"><\/span>Stress<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>In situations of acute stress, the sympathetic system is activated, and the <b>HPA axis<\/b> (hypothalamic-pituitary-adrenal), with transient changes in pain threshold. When stress is sustained, the sustained elevation of cortisol and catecholamines can alter nociceptive processing in medulla and cortex, favouring processes of <b>central awareness<\/b>, hypervigilance and increased reactivity to stimuli. Accompanying factors such as muscle tension or shallow breathing may reinforce these loops. The magnitude of the effect varies according to individual vulnerability and concomitant clinical conditions.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Sueno\"><\/span>Dream<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Insufficient or fragmented sleep, in particular the reduction of sleep <b>slow-wave sleep<\/b>, is associated with a reduced effectiveness of the <b>downstream inhibitory pathways<\/b> and increased nociceptive facilitation. Frequent awakenings and irregular rhythms may lower the next day's pain threshold and increase symptom variability. The relationship is bidirectional: pain also alters sleep architecture, so changes are often fluctuating and modulated by factors such as age, drugs and comorbidities.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Actividad_fisica\"><\/span>Physical activity<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Dosed and progressive physical activity can influence pain perception through the activation of pain sensing systems. <b>endogenous analgesia<\/b> (opioid and endocannabinoid), adjustments to the <b>autonomous tone<\/b> and adaptations in cortical excitability related to movement. It may also contribute to more efficient motor control, with less load on sensitive structures. However, peak loads, unadapted intensities or poor technique can transiently increase sensitivity. The response is heterogeneous and depends on the type of activity, the dose and the clinical context.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Diferencias_entre_dolor_agudo_cronico_y_neuropatico_en_la_regulacion_neurologica_y_la_forma_de_percibirlo\"><\/span>Differences between acute, chronic and neuropathic pain in neurological regulation and perception of pain<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"Dolor_agudo\"><\/span>Acute pain<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Acute pain is a protective response that is caused by the activation of <b>nociceptors<\/b> (A\u03b4 and C fibres) in response to tissue injury or inflammation. The signal ascends via spinal pathways to thalamic and cortical structures, and is modulated at different levels by local segmental and segmental mechanisms. <b>downhill tracks<\/b> inhibitory and facilitative. Perception is often <b>reachable<\/b>, proportional to the stimulus, with a stinging or lacerating quality, and may be accompanied by <b>peripheral sensitisation<\/b> (hypersensitivity in the injured area due to inflammatory mediators).<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Dolor_cronico\"><\/span>Chronic pain<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Chronic pain persists beyond the expected time of tissue repair (often considered to be &gt;3 months) and is associated with changes of <b>neuroplasticity<\/b> which include <b>central awareness<\/b> (increased excitability of neurons in spinal cord and brain), decreased inhibitory control and downward facilitation. Clinically, it may be perceived as more diffuse or fluctuating, with <b>hyperalgesia<\/b> y <b>allodynia<\/b>, and a disproportion between stimulus and pain intensity. Attentional and emotional factors may modulate its expression by interacting with cortical networks involved in the assessment and meaning of pain.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Dolor_neuropatico\"><\/span>Neuropathic pain<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Neuropathic pain is caused by injury or disease of the somatosensory system, peripheral or central. It usually involves ectopic activity, changes in ion channels and rearrangement of circuits with reduced inhibitory control and <b>awareness-raising<\/b> maintained. Perception often includes <b>burning<\/b>, <b>electrical discharges<\/b>, tingling or spontaneous pain, with <b>allodynia<\/b> and areas of hypoaesthesia or dysaesthesia in neuroanatomical distributions (e.g. dermatomes). Pain evoked by mild stimuli and pain without apparent stimuli due to aberrant activation of nociceptive pathways may coexist.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Opciones_terapeuticas_con_base_cientifica_para_apoyar_la_regulacion_neurologica_y_una_percepcion_del_dolor_mas_tolerable\"><\/span>Science-based therapeutic options to support neurological regulation and a more tolerable perception of pain<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>In order to promote a <b>neurological regulation<\/b> and a more tolerable perception of pain, approaches are used that modulate the <b>neuroplasticity<\/b> and the possible <b>central awareness<\/b>, prioritising a multimodal and prudent approach, adjusted to the pain profile (nociceptive, neuropathic or non-disciplinary) and comorbidities. The response varies from person to person and requires clinical follow-up to assess the risk-benefit balance.<\/p>\n<p>In the psychological and behavioural domain, several interventions have empirical support for improving coping and nervous system reactivity:<\/p>\n<ul>\n<li><b>Cognitive behavioural therapy<\/b> and acceptance approaches (ACT): work on expectations, catastrophising and avoidance, with impact on pain and stress circuits.<\/li>\n<li><b>Mindfulness\/MBSR<\/b>training non-reactive attention; has been associated with changes in autonomic reactivity and in the subjective experience of pain.<\/li>\n<li><b>Education in pain neuroscience<\/b>Improves understanding of the symptom and can reduce fear-avoidance and hypervigilance.<\/li>\n<li><b>Biofeedback<\/b> (e.g. heart rate variability) and <b>slow breathing<\/b>aimed at balancing sympathetic-parasympathetic tone.<\/li>\n<li><b>Sleep interventions<\/b> (hygiene and CBT-I): insufficient sleep is associated with increased sensitisation; addressing it may modulate the pain response.<\/li>\n<\/ul>\n<p>Physical and movement strategies aim to restore function and modulate nociceptive pathways in a graded manner:<\/p>\n<ul>\n<li><b>Progressive aerobic exercise<\/b> y <b>strength training<\/b>The following are the most important factors: dosed to avoid exacerbations, they promote conditioning and endogenous mechanisms of pain modulation.<\/li>\n<li><b>Physiotherapy<\/b> with graded exposure, motor control and pacing: aimed at restoring movement patterns and reducing fear of pain.<\/li>\n<li><b>Sensorimotor training<\/b> (graded motor imagery, mirror): can help in cases of body schema distortion or allodynia.<\/li>\n<li><b>TENS<\/b> and other non-invasive techniques: low-risk supportive option; clinical response is heterogeneous.<\/li>\n<\/ul>\n<p>At the pharmacological and neuromodulation level, adjuvant options are considered according to pain phenotype and tolerability:<\/p>\n<ul>\n<li><b>Adjuvant drugs<\/b> in neuropathic\/non-disciplinary pain: serotonin-norepinephrine reuptake inhibitors (e.g. duloxetine), <b>tricyclics<\/b> at low doses (amitriptyline), <b>gabapentinoides<\/b> (gabapentin\/pregabalin) and topicals (lidocaine, capsaicin) are used on an individualised basis with periodic reassessment of efficacy and adverse effects.<\/li>\n<li><b>NSAIDs and paracetamol<\/b>limited usefulness in chronic pain with central predominance; can be considered in specific nociceptive components according to risk profile.<\/li>\n<li><b>Invasive neuromodulation<\/b> (spinal cord or dorsal root ganglion stimulation): reserved for selected, refractory cases after specialist assessment; results vary between patients.<\/li>\n<li><b>Addressing co-morbidities<\/b> (mood, anxiety, trauma, consumption) and correction of documented deficiencies (e.g. B12, vitamin D) can influence the reactivity of the nervous system.<\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Regulaci\u00f3n neurol\u00f3gica y percepci\u00f3n del dolor: qu\u00e9 significan y por qu\u00e9 importan La regulaci\u00f3n neurol\u00f3gica es la capacidad del sistema nervioso para filtrar, amplificar o atenuar las se\u00f1ales relacionadas con da\u00f1o potencial. La percepci\u00f3n del dolor no es equivalente a la nocicepci\u00f3n (detecci\u00f3n de est\u00edmulos nocivos); es una experiencia sensorial y emocional que integra se\u00f1ales [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":5250,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[28],"tags":[],"class_list":["post-5246","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-quiropractica-y-sistema-nervioso"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.saludquiropractica.es\/en\/wp-json\/wp\/v2\/posts\/5246","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.saludquiropractica.es\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.saludquiropractica.es\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.saludquiropractica.es\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.saludquiropractica.es\/en\/wp-json\/wp\/v2\/comments?post=5246"}],"version-history":[{"count":0,"href":"https:\/\/www.saludquiropractica.es\/en\/wp-json\/wp\/v2\/posts\/5246\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.saludquiropractica.es\/en\/wp-json\/wp\/v2\/media\/5250"}],"wp:attachment":[{"href":"https:\/\/www.saludquiropractica.es\/en\/wp-json\/wp\/v2\/media?parent=5246"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.saludquiropractica.es\/en\/wp-json\/wp\/v2\/categories?post=5246"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.saludquiropractica.es\/en\/wp-json\/wp\/v2\/tags?post=5246"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}